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In this review, we have summarized cancer-associated genomic, transcriptomic, and mutation profile repositories. In the last few decades, several computational methods and resources have been developed for designing immunotherapy against cancer. Recent preferments in high-throughput sequencing and computational immunology leads to the development of targeted immunotherapy for precision oncology. It acts as a novel pillar for treating different malignancies from their primary to the metastatic stage. Overall survival of cancer patients has improved significantly due to the use of immunotherapy. Immunotherapy is a rapidly growing therapy for cancer which have numerous benefits over conventional treatments like surgery, chemotherapy, and radiation.
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The CKTTD database is freely available to public at. In conclusion, the CKTTD may serve as a useful platform for the research of cancer immunotherapy and drug discovery. In total, CKTTD compiles 105 checkpoint protein targets, 53 modulators (small-molecules and antibody), 30 miRNAs and 18 LncRNAs in cancer immunotherapy with validated experimental evidences curated from 10 649 literatures via an enhanced text-mining system. Moreover, we computed and provided ligand-binding site information for all the targets which may support bench scientists for drug discovery efforts. In addition, a few biological databases such as Oncomine, Drugbank, miRBase and Lnc2Cancer database were integrated into CKTTD to provide an in-depth information. A scoring system was adopted to filter more relevant targets with high confidence. To this end, we developed checkpoint therapeutic target database (CKTTD), the first comprehensive database for immune checkpoint targets (proteins, miRNAs and LncRNAs) and their modulators. Unfortunately, there is a lack of bioinformatics resource that compile all the checkpoint targets for translational research and drug discovery in immuno-oncology. Checkpoint targets play a key role in tumor-mediated immune escape and therefore are critical for cancer immunotherapy.
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